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Pathways Recommended: Antibody-drug Conjugate/ADC Related
Results for "

IgG2 monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

1

MCE Kits

35

Inhibitory Antibodies

Cat. No. Product Name Target Research Area
  • HY-P99901
    Sibeprenlimab

    VIS649

    		 Inhibitory Antibodies Cancer
    Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody. Sibeprenlimab can inhibit APRIL. Sibeprenlimab can be used for the research of IgA nephropathy (IgAN) .
  • HY-P99589
    Sotevtamab

    16B5; AB-16B5

    		 Apoptosis Cancer
    Sotevtamab (16B5) is a humanized IgG2 anti-clusterin monoclonal antibody (mAb). Sotevtamab is an inhibitor of the epithelial to mesenchymal transition. Sotevtamab can be used for cancer research .
  • HY-P99332
    Visilizumab

    Anti-Human CD3E Recombinant antibody; HuM291

    		 Apoptosis Inflammation/Immunology
    Visilizumab (Anti-Human CD3E Recombinant Antibody) is a humanized low-Fc receptor binding anti-CD3 monoclonal IgG2 antibody. Visilizumab can be used for ulcerative colitis and Crohn's disease research .
  • HY-P99205
    Glembatumumab

    		ADC Antibody Cancer
    Glembatumumab is a fully human IgG2 monoclonal antibody directed against the extracellular structural domain of GPNMB expressed in human breast cancer and melanoma. Glembatumumab can be coupled to the microtubule inhibitor monomethyl auristatin E to form glembatumumab vedotin. Glembatumumab vedotin is an antibody-agent coupling (ADC) with antitumor activity .
  • HY-P99465
    Befovacimab

    BAY 1093884

    		 Thrombin Cardiovascular Disease
    Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research .
  • HY-P99444
    Astegolimab
    1 Publications Verification

    MSTT 1041A; RG 6149

    		 Interleukin Related Inflammation/Immunology
    Astegolimab (MSTT 1041A; RG 6149) is a human IgG2 monoclonal antibody that blocks IL-33 signaling by targeting ST2, the IL-33 receptor. Astegolimab has the potential for chronic obstructive pulmonary disease (COPD) research .
  • HY-P99041
    Panitumumab
    1 Publications Verification

    ABX-EGF

    		 EGFR Cancer
    Panitumumab (ABX-EGF) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab can be used in the research of cancers, such as colon cancer .
  • HY-P99041A
    Panitumumab (anti-EGFR)

    		EGFR Cancer
    Panitumumab (anti-EGFR) is a fully human IgG2 anti-EGFR monoclonal antibody with anti-tumor activity. Panitumumab (anti-EGFR) inhibits tumor cell proliferation, survival and angiogenesis. Panitumumab (anti-EGFR) can be used in the research of cancers, such as colon cancer .
  • HY-P99002
    Human IgG2 kappa, Isotype Control

    		Inhibitory Antibodies Inflammation/Immunology
    Human IgG2 kappa, Isotype Control, a human-mouse chimeric monoclonal antibody, is an isotype control for human IgG2κ antibody.
  • HY-P99200
    Fulranumab

    		Inhibitory Antibodies Neurological Disease
    Fulranumab is a human IgG2 monoclonal antibody against nerve growth factor (NGF) and can be used for the research of pain .
  • HY-P99438
    Anivovetmab

    KIND-030

    		 Inhibitory Antibodies Infection
    Anivovetmab (KIND-030) is an anti-VP2 (parvovirus major capsid protein) monoclonal antibody (IgG2 type). Anivovetmab has the potential to study canine parvovirus infection.
  • HY-P99320
    Tarextumab

    OMP 59R5; Anti-Human NOTCH2 Recombinant antibody

    		 Notch Cancer
    Tarextumab (OMP-59R5) is an anti-Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity .
  • HY-P9925
    Brodalumab
    1 Publications Verification

    AMG 827; KHK4827

    		 Interleukin Related Inflammation/Immunology
    Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis .
  • HY-P99411
    Ontamalimab

    SHP647

    		 Inhibitory Antibodies Inflammation/Immunology
    Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease .
  • HY-P99485
    Brazikumab

    AMG 139; MEDI2070

    		 Interleukin Related Inflammation/Immunology
    Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a KD of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .
  • HY-P99183
    Abituzumab

    EMD 525797; DI17E6

    		 Integrin Cancer
    Abituzumab (DI17E6) is a humanised anti-integrin αV monoclonal antibody (IgG2 type). Abituzumab effectively reduces the phosphorylation of FAK, Akt and ERK. Abituzumab can be used in cancer research, particularly in prostate cancer .
  • HY-P99353
    Ascrinvacumab

    Anti-ACVRL1 / ALK-1 Reference antibody (ascrinvacumab); PF-03446962

    		 Anaplastic lymphoma kinase (ALK) Cancer
    Ascrinvacumab (PF-03446962) is a human IgG2 monoclonal antibody targets ALK-1. Ascrinvacumab shows binding efficiency with human ALK1 with a Kd value of 7 nM. Ascrinvacumab can be used for the research of hepatocellular carcinoma (HCC) .
  • HY-P99216
    Ponezumab

    PF-04360365; RN 1219

    		 EGFR Neurological Disease
    Ponezumab (PF-04360365) is a humanised anti-amyloid IgG2 monoclonal antibody. Ponezumab reduces Aβ levels in the central nervous system and improves performance in mice in various models of learning and memory. Ponezumab can be used in study of Alzheimer's disease .
  • HY-P99729
    Melrilimab

    GSK 3772847; CNTO-7160

    		 Interleukin Related Inflammation/Immunology
    Melrilimab (GSK 3772847) is an IgG2-kappa anti-IL1RL1/ST2/IL33R/DER4/FIT-1 monoclonal antibody. Melrilimab can be used for the research of asthma .
  • HY-P99414
    Prezalumab

    AMG 557

    		 Inhibitory Antibodies Inflammation/Immunology
    Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE) .
  • HY-P99268
    Seribantumab

    SAR 256212; MM 121; Anti-Human ERBB3/ErbB 3 Recombinant antibody

    		 EGFR Apoptosis Cancer
    Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models .
  • HY-P9974
    Vantictumab

    OMP-18R5

    		 Wnt Cancer
    Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab is being studied against cancers such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .
  • HY-P99978
    Mouse IgG2a kappa, Isotype Control

    		Inhibitory Antibodies Inflammation/Immunology
    Mouse IgG2a kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG2aκ antibody.
  • HY-P99981
    Mouse IgG2c kappa, Isotype Control

    		Inhibitory Antibodies Inflammation/Immunology
    Mouse IgG2c kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG2cκ antibody.
  • HY-P99982
    Mouse IgG2b kappa, Isotype Control

    		Inhibitory Antibodies Inflammation/Immunology
    Mouse IgG2b kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse IgG2bκ antibody.
  • HY-P99677
    Izenivetmab

    ZTS-00075623

    		 Inhibitory Antibodies Neurological Disease
    Izenivetmab (ZTS-00075623) is a caninized IgG2κ anti-NGFB monoclonal antibody .
  • HY-P99867
    Dusigitumab

    MEDI 573

    		 IGF-1R Others
    Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody that specifically targets IGF2 and IGF1 .
  • HY-P99326
    Tositumomab

    Anti-Human CD20 Recombinant antibody

    		 CD20 Cancer
    Tositumomab is a murine IgG2a lambda monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes .
  • HY-P99743
    Mitumomab

    		Inhibitory Antibodies Cancer
    Mitumomab is an anti-idiotypic mouse IgG2b monoclonal antibody that mimics the ganglioside GD3. Mitumomab can be used for the research of small-cell lung carcinoma .
  • HY-P99366
    Tezepelumab

    AMG 157; MEDI 19929; Tezepelumab-ekko

    		 Inhibitory Antibodies Inflammation/Immunology
    Tezepelumab (AMG 157) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP, blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma .
  • HY-P99466
    Begelomab

    SAND-26

    		 Dipeptidyl Peptidase Inflammation/Immunology
    Begelomab (SAND-26) is a murine IgG2b monoclonal antibody against DPP-4/CD26. Begelomab can be used for the research of severe refractory idiopathic inflammatory myopathy .
  • HY-P99650
    Grisnilimab

    WT1

    		 Inhibitory Antibodies Cancer
    Grisnilimab (WT1), a IgG2a monoclonal antibody anti-CD7, is a tumor suppressor involved in the etiology of Wilms' tumor. Grisnilimab regulates the transcription of multiple target genes and may participate in the post-transcriptional processing of RNA .
  • HY-P99019
    Fremanezumab

    TEV-48125

    		 CGRP Receptor Neurological Disease
    Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP). CGRP is a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab has the potential for chronic migraine research .
  • HY-P99336
    Enlimomab

    BI-RR 0001; Anti-Human IL6 Recombinant antibody

    		 Integrin Neurological Disease Inflammation/Immunology
    Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research .
  • HY-P99837
    Dafsolimab

    SPV-T3a

    		 CD3 Infection
    Dafsolimab (SPV-T3a) is an IgG2a murine monoclonal antibody (anti-CD3). Dafsolimab can induce cell death through modulation and activation of the CD3/T cell receptor complex. Dafsolimab can be used for the research of graft-versus-host disease (GVHD) .

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